|
KMID : 0880520080440030169
|
|
Chonnam Medical Journal
2008 Volume.44 No. 3 p.169 ~ p.176
|
|
|
Effects of Propofol and Gabexate Mesilate (Foy) on Endotoxin-induced Acute Lung Injury in Rabbit
|
|
Chung Sung-Su
Kim Seok-Jae
Kwak Sang-Hyun
Bae Hong-Beom
Jeong Cheol-Won
Jeung Hye-Jin
Li Mai
|
|
|
Abstract
|
|
|
|
This study was to clarify the effects of propofol and gabexate mesilate (foy), a synthetic protease inhibitor, on endotoxin induced-acute lung injury in rabbit. Animals were randomly assigned to one of five groups. Each group received intravenous infusion of saline only, saline and Escherichia coli endotoxin, propofol (4 mg/kg bolus, then 20 mg/kg/hr) and endotoxin, foy (2 mg/kg bolus, then 2 mg/kg/hr) and endotoxin and propofol (4 mg/kg bolus, then 20 mg/kg/hr) plus foy (2 mg/kg bolus, then 2 mg/kg/hr) and endotoxin. Infusion of saline, propofol or foy was started 30 minutes before the infusion of saline or endotoxin, and continued for 6 hours thereafter. At the end of infusion, animals were sacrificed and the wet to dry (W/D) weight ratio of lung, lung injury score, leukocyte counts, percentage of polymorphonuclear leukocyte (PMNL), and concentrations of albumin and interleukin-8 (IL-8) in bronchoalveolar lavage fluid (BALF) were evaluated. Endotoxin decreased the PaO2 and peripheral blood leukocyte and platelet counts. And it increased the W/D weight ratio of lung, the lung injury score, leukocyte counts, percentage of PNML, and concentration of albumin and IL-8 in BALF. Each propofol or foy attenuated all these changes except the leukocyte count in peripheral blood. These findings suggest that each propofol or foy attenuates endotoxin-induced acute lung injury in rabbit by inhibiting neutrophil, IL-8 and platelet responses which may play a central role in sepsis related lung injury. But both propofol and foy do not show synergic effect.
|
|
|
KEYWORD
|
|
|
Acute lung injury, Endotoxin, Gabexate mesilate (foy), Propofol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|